The National Alliance of State Drug Enforcement Agencies (NASDEA) was established in 1975 to foster greater cooperation and coordination between state drug law enforcement agencies; provide input to federal-level policy, procedures, and operations; and provide a forum for the exchange of information regarding best practices in drug law enforcement among its member agencies. 

NASDEA member agencies are state law enforcement agencies with primary authority of enforcing the controlled substances laws of their state. Depending on the state these agencies might be from state investigative bureaus, state police, or the agency responsible for statewide criminal drug enforcement investigations.

Operational members of NASDEA are command level staff representing their state agency from all fifty states, the Commonwealth of Puerto Rico and the Virgin Islands of the United States working together to keep their states and Americans safe from dangerous drugs and those involved in trafficking them.